Cargando…
Expanding the drug discovery space with predicted metabolite–target interactions
Metabolites produced in the human gut are known modulators of host immunity. However, large-scale identification of metabolite–host receptor interactions remains a daunting challenge. Here, we employed computational approaches to identify 983 potential metabolite–target interactions using the Inflam...
Autores principales: | Nuzzo, Andrea, Saha, Somdutta, Berg, Ellen, Jayawickreme, Channa, Tocker, Joel, Brown, James R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935942/ https://www.ncbi.nlm.nih.gov/pubmed/33674782 http://dx.doi.org/10.1038/s42003-021-01822-x |
Ejemplares similares
-
Expanding and understanding metabolite space
por: Peironcely, Julio E, et al.
Publicado: (2010) -
Expanding roles for academic entrepreneurship in drug discovery
por: Kinch, Michael S., et al.
Publicado: (2020) -
Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery
por: Morrison, Christine N., et al.
Publicado: (2019) -
Indole microbial metabolites: expanding and translating target(s)
por: Mani, Sridhar
Publicado: (2017) -
Computational Discovery of Putative Leads for Drug Repositioning through Drug-Target Interaction Prediction
por: Coelho, Edgar D., et al.
Publicado: (2016)