Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes ribosome stalling and suppresses protein synthesis in mouse HD striatal neuronal cells. Depletion of mHtt enhances protein synth...

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Detalles Bibliográficos
Autores principales: Eshraghi, Mehdi, Karunadharma, Pabalu P., Blin, Juliana, Shahani, Neelam, Ricci, Emiliano P., Michel, Audrey, Urban, Nicolai T., Galli, Nicole, Sharma, Manish, Ramírez-Jarquín, Uri Nimrod, Florescu, Katie, Hernandez, Jennifer, Subramaniam, Srinivasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935949/
https://www.ncbi.nlm.nih.gov/pubmed/33674575
http://dx.doi.org/10.1038/s41467-021-21637-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935949/
https://www.ncbi.nlm.nih.gov/pubmed/33674575
http://dx.doi.org/10.1038/s41467-021-21637-y

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