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RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks
Ubiquitination-dependent DNA damage response (DDR) signals play a critical role in the cellular choice of DNA damage repair pathways. Human DNA helicase RecQL4 participates in DNA replication and repair, and loss of RecQL4 is associated with autosomal recessive genetic disorders characterized by gen...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935965/ https://www.ncbi.nlm.nih.gov/pubmed/33674555 http://dx.doi.org/10.1038/s41389-021-00315-0 |