Loci-specific phase separation of FET fusion oncoproteins promotes gene transcription

Abnormally formed FUS/EWS/TAF15 (FET) fusion oncoproteins are essential oncogenic drivers in many human cancers. Interestingly, at the molecular level, they also form biomolecular condensates at specific loci. However, how these condensates lead to gene transcription and how features encoded in the...

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Detalles Bibliográficos
Autores principales: Zuo, Linyu, Zhang, Guanwei, Massett, Matthew, Cheng, Jun, Guo, Zicong, Wang, Liang, Gao, Yifei, Li, Ru, Huang, Xu, Li, Pilong, Qi, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935978/
https://www.ncbi.nlm.nih.gov/pubmed/33674598
http://dx.doi.org/10.1038/s41467-021-21690-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935978/
https://www.ncbi.nlm.nih.gov/pubmed/33674598
http://dx.doi.org/10.1038/s41467-021-21690-7

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