Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma

Volatile aldehydes are enriched in esophageal adenocarcinoma (EAC) patients’ breath and could improve early diagnosis, however the mechanisms of their production are unknown. Here, we show that weak aldehyde detoxification characterizes EAC, which is sufficient to cause endogenous aldehyde accumulat...

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Detalles Bibliográficos
Autores principales: Antonowicz, Stefan, Bodai, Zsolt, Wiggins, Tom, Markar, Sheraz R., Boshier, Piers R., Goh, Yan Mei, Adam, Mina E., Lu, Haonan, Kudo, Hiromi, Rosini, Francesca, Goldin, Robert, Moralli, Daniela, Green, Catherine M., Peters, Chris J., Habib, Nagy, Gabra, Hani, Fitzgerald, Rebecca C., Takats, Zoltan, Hanna, George B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935981/
https://www.ncbi.nlm.nih.gov/pubmed/33674602
http://dx.doi.org/10.1038/s41467-021-21800-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935981/
https://www.ncbi.nlm.nih.gov/pubmed/33674602
http://dx.doi.org/10.1038/s41467-021-21800-5

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