Discovery and characterization of bromodomain 2–specific inhibitors of BRDT

Bromodomain testis (BRDT), a member of the bromodomain and extraterminal (BET) subfamily that includes the cancer targets BRD2, BRD3, and BRD4, is a validated contraceptive target. All BET subfamily members have two tandem bromodomains (BD1 and BD2). Knockout mice lacking BRDT-BD1 or both bromodomai...

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Detalles Bibliográficos
Autores principales: Yu, Zhifeng, Ku, Angela F., Anglin, Justin L., Sharma, Rajesh, Ucisik, Melek Nihan, Faver, John C., Li, Feng, Nyshadham, Pranavanand, Simmons, Nicholas, Sharma, Kiran L., Nagarajan, Sureshbabu, Riehle, Kevin, Kaur, Gundeep, Sankaran, Banumathi, Storl-Desmond, Marta, Palmer, Stephen S., Young, Damian W., Kim, Choel, Matzuk, Martin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936271/
https://www.ncbi.nlm.nih.gov/pubmed/33637650
http://dx.doi.org/10.1073/pnas.2021102118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936271/
https://www.ncbi.nlm.nih.gov/pubmed/33637650
http://dx.doi.org/10.1073/pnas.2021102118

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