Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets

We evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor (Ab-4) to maintain glucose homeostasis in type 1 diabetic rodents. We noted durable and sustained improvements in glycemia which persist long after treatment withdrawal. Ab-4 promoted β-cell survival and enhance...

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Detalles Bibliográficos
Autores principales: Wang, May-Yun, Dean, E. Danielle, Quittner-Strom, Ezekiel, Zhu, Yi, Chowdhury, Kamrul H., Zhang, Zhuzhen, Zhao, Shangang, Li, Na, Ye, Reshing, Lee, Young, Zhang, Yiyi, Chen, Shiuhwei, Yu, Xinxin, Leonard, Derek C., Poffenberger, Greg, Von Deylen, Alison, McCorkle, S. Kay, Schlegel, Amnon, Sloop, Kyle W., Efanov, Alexander M., Gimeno, Ruth E., Scherer, Philipp E., Powers, Alvin C., Unger, Roger H., Holland, William L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936318/
https://www.ncbi.nlm.nih.gov/pubmed/33619103
http://dx.doi.org/10.1073/pnas.2022142118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936318/
https://www.ncbi.nlm.nih.gov/pubmed/33619103
http://dx.doi.org/10.1073/pnas.2022142118

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