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The CAD risk locus 9p21 increases the risk of vascular calcification in an iPSC-derived VSMC model

BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide. Chromosome locus 9p21 was the first to be associated with increased risk of CAD and coronary artery calcification (CAC). Vascular calcification increases the risk for CAD. Vascular smooth muscle cells (VSMCs) are one...

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Detalles Bibliográficos
Autores principales: Trillhaase, Anja, Schmidt, Beatrice, Märtens, Marlon, Haferkamp, Undine, Erdmann, Jeanette, Aherrahrou, Zouhair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936418/
https://www.ncbi.nlm.nih.gov/pubmed/33676559
http://dx.doi.org/10.1186/s13287-021-02229-5