Cargando…
Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration
OBJECTIVE: To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics. METHODS: This study includes n = 66 primary OA patients (41 knees and 25 hips), who underwent a joi...
Autores principales: | Coutinho de Almeida, Rodrigo, Mahfouz, Ahmed, Mei, Hailiang, Houtman, Evelyn, den Hollander, Wouter, Soul, Jamie, Suchiman, Eka, Lakenberg, Nico, Meessen, Jennifer, Huetink, Kasper, Nelissen, Rob G H H, Ramos, Yolande F M, Reinders, Marcel, Meulenbelt, Ingrid |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937023/ https://www.ncbi.nlm.nih.gov/pubmed/32885253 http://dx.doi.org/10.1093/rheumatology/keaa391 |
Ejemplares similares
-
Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis
por: Coutinho de Almeida, Rodrigo, et al.
Publicado: (2022) -
RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage
por: Coutinho de Almeida, Rodrigo, et al.
Publicado: (2019) -
Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers
por: Ramos, Yolande F. M., et al.
Publicado: (2021) -
Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis
por: Houtman, Evelyn, et al.
Publicado: (2021) -
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes
por: Houtman, Evelyn, et al.
Publicado: (2022)