ApoE4 (Δ272–299) induces mitochondrial‐associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron

BACKGROUND: Apolipoprotein E4 (apoE4) is a major genetic risk factor of Alzheimer’s disease. Its C-terminal-truncated apoE4 (Δ272–299) has neurotoxicity by affecting mitochondrial respiratory function. However, the molecular mechanism(s) underlying the action of apoE4 (Δ272–299) in mitochondrial fun...

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Detalles Bibliográficos
Autores principales: Liang, Tao, Hang, Weijian, Chen, Jiehui, Wu, Yue, Wen, Bin, Xu, Kai, Ding, Bingbing, Chen, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937300/
https://www.ncbi.nlm.nih.gov/pubmed/33676568
http://dx.doi.org/10.1186/s13578-021-00563-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937300/
https://www.ncbi.nlm.nih.gov/pubmed/33676568
http://dx.doi.org/10.1186/s13578-021-00563-y

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