Cargando…

ApoE4 (Δ272–299) induces mitochondrial‐associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron

BACKGROUND: Apolipoprotein E4 (apoE4) is a major genetic risk factor of Alzheimer’s disease. Its C-terminal-truncated apoE4 (Δ272–299) has neurotoxicity by affecting mitochondrial respiratory function. However, the molecular mechanism(s) underlying the action of apoE4 (Δ272–299) in mitochondrial fun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Tao, Hang, Weijian, Chen, Jiehui, Wu, Yue, Wen, Bin, Xu, Kai, Ding, Bingbing, Chen, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937300/ https://www.ncbi.nlm.nih.gov/pubmed/33676568 http://dx.doi.org/10.1186/s13578-021-00563-y

Ejemplares similares

Preserving mitochondrial function by inhibiting GRP75 ameliorates neuron injury under ischemic stroke
por: Wen, Bin, et al.
Publicado: (2022)

Calcium Overload and Mitochondrial Metabolism
por: Walkon, Lauren L., et al.
Publicado: (2022)

Miro1 R272Q disrupts mitochondrial calcium handling and neurotransmitter uptake in dopaminergic neurons
por: Schwarz, Lisa, et al.
Publicado: (2022)

Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells
por: Nakamura, Toshiyuki, et al.
Publicado: (2009)

Modeling the Effects of Calcium Overload on Mitochondrial Ultrastructural Remodeling
por: Strubbe-Rivera, Jasiel O., et al.
Publicado: (2021)

Mitochondrial metabolic regulation by GRP78
por: Prasad, Manoj, et al.
Publicado: (2017)

The antidepressant fluoxetine induces necrosis by energy depletion and mitochondrial calcium overload
por: Charles, Emilie, et al.
Publicado: (2016)

Nobiletin attenuates neurotoxic mitochondrial calcium overload through K(+) influx and ΔΨ(m) across mitochondrial inner membrane
por: Lee, Ji Hyung, et al.
Publicado: (2018)

The mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function
por: Strubbe-Rivera, Jasiel O., et al.
Publicado: (2021)

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons
por: Kostic, Marko, et al.
Publicado: (2015)

Mitochondrial calcium cycling in neuronal function and neurodegeneration
por: Walters, Grant C., et al.
Publicado: (2023)

TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy
por: Li, Yan, et al.
Publicado: (2023)

Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart
por: Dridi, Haikel, et al.
Publicado: (2023)

Ca(2+) overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells
por: Raimondi, Michela, et al.
Publicado: (2021)

IP(3)R at ER-Mitochondrial Contact Sites: Beyond the IP(3)R-GRP75-VDAC1 Ca(2+) Funnel
por: Atakpa-Adaji, Peace, et al.
Publicado: (2023)

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload
por: Egnatchik, Robert A., et al.
Publicado: (2014)

Iron Overload, Oxidative Stress and Calcium Mishandling in Cardiomyocytes: Role of the Mitochondrial Permeability Transition Pore
por: Gordan, Richard, et al.
Publicado: (2020)

Akkermansia muciniphila induces mitochondrial calcium overload and α -synuclein aggregation in an enteroendocrine cell line
por: Amorim Neto, Dionísio Pedro, et al.
Publicado: (2022)

Mild Traumatic Brain Injury Induces Mitochondrial Calcium Overload and Triggers the Upregulation of NCLX in the Hippocampus
por: Mira, Rodrigo G., et al.
Publicado: (2023)

APOE expression and secretion are modulated by mitochondrial dysfunction
por: Wynne, Meghan E, et al.
Publicado: (2023)

Overexpression of Mitochondrial Calcium Uniporter Causes Neuronal Death
por: Granatiero, Veronica, et al.
Publicado: (2019)

The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells
por: Zhang, Linlin, et al.
Publicado: (2022)

Mitochondrial calcium homeostasis as potential target for mitochondrial medicine
por: Giorgi, Carlotta, et al.
Publicado: (2012)

4-hydroxy-2(E)-Nonenal facilitates NMDA-Induced Neurotoxicity via Triggering Mitochondrial Permeability Transition Pore Opening and Mitochondrial Calcium Overload
por: Choi, In-Young, et al.
Publicado: (2013)

PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca(2+) efflux
por: Zhou, Qin, et al.
Publicado: (2021)

IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling
por: Yuan, Ming, et al.
Publicado: (2022)

Calcium chelator BAPTA-AM protects against iron overload-induced chondrocyte mitochondrial dysfunction and cartilage degeneration
por: Jing, Xingzhi, et al.
Publicado: (2021)

Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload
por: Ge, Chentao, et al.
Publicado: (2019)

Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors
por: McElnea, E.M., et al.
Publicado: (2011)

Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death
por: Sun, Yue, et al.
Publicado: (2022)

Visible‐Light‐Activated Molecular Machines Kill Fungi by Necrosis Following Mitochondrial Dysfunction and Calcium Overload
por: Santos, Ana L., et al.
Publicado: (2023)

Mitochondrial Ca(2+) Overload Leads to Mitochondrial Oxidative Stress and Delayed Meiotic Resumption in Mouse Oocytes
por: Zhang, Luyao, et al.
Publicado: (2020)

Mitochondrial DNA mutations affect calcium handling in differentiated neurons
por: Trevelyan, Andrew J., et al.
Publicado: (2010)

Oxidative stress induces mitochondrial iron overload and ferroptotic cell death
por: Chen, Yi, et al.
Publicado: (2023)

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter (MCU)
por: Pan, Xin, et al.
Publicado: (2013)

Upregulation of Phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in Acquired Middle Ear Cholesteatoma Growth
por: Ho, Kuen Yao, et al.
Publicado: (2013)

Nuclear GRP75 Binds Retinoic Acid Receptors to Promote Neuronal Differentiation of Neuroblastoma
por: Shih, Yu-Yin, et al.
Publicado: (2011)

Immediate response of myocardium to pressure overload includes transient regulation of genes associated with mitochondrial bioenergetics and calcium availability
por: Deckmann, Ana Carolina, et al.
Publicado: (2010)

Changes in the Stoichiometry of Uniplex Decrease Mitochondrial Calcium Overload and Contribute to Tolerance of Cardiac Ischemia/Reperfusion Injury in Hypothyroidism
por: Chapoy-Villanueva, Héctor, et al.
Publicado: (2019)

Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease
por: Soman, Smijin K., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qd7krng5usl63qej304a0df8sc