Method Development and Validation for Measuring O(6)-Methylguanine in Dried Blood Spot Using Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry

BACKGROUND: Cyclophosphamide is a nitrogen mustard chemotherapy drug that damages DNA through alkylation in the DNA base and produces DNA adducts. Alkylation that occurs in the N7 position of guanine base has a cytotoxic effect which is useful for cancer therapy. However, the alkylation that occurs...

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Detalles Bibliográficos
Autores principales: Harahap, Yahdiana, Vianney, Aurelia Maria, Suryadi, Herman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937437/
https://www.ncbi.nlm.nih.gov/pubmed/33692614
http://dx.doi.org/10.2147/DDDT.S283775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937437/
https://www.ncbi.nlm.nih.gov/pubmed/33692614
http://dx.doi.org/10.2147/DDDT.S283775

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