Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death

Receptor-interacting protein 1 (RIP1; RIPK1) is a key regulator of multiple signaling pathways that mediate inflammatory responses and cell death. TNF-TNFR1 triggered signaling complex formation, subsequent NF-κB and MAPK activation and induction of cell death involve RIPK1 ubiquitination at several...

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Detalles Bibliográficos
Autores principales: Kist, Matthias, Kőműves, László G., Goncharov, Tatiana, Dugger, Debra L., Yu, Charles, Roose-Girma, Merone, Newton, Kim, Webster, Joshua D., Vucic, Domagoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937686/
https://www.ncbi.nlm.nih.gov/pubmed/32999468
http://dx.doi.org/10.1038/s41418-020-00629-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937686/
https://www.ncbi.nlm.nih.gov/pubmed/32999468
http://dx.doi.org/10.1038/s41418-020-00629-3

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