Icaritin Alleviates Glutamate-Induced Neuronal Damage by Inactivating GluN2B-Containing NMDARs Through the ERK/DAPK1 Pathway

Excitatory toxicity due to excessive glutamate release is considered the core pathophysiological mechanism of cerebral ischemia. It is primarily mediated by N-methyl-D-aspartate receptors (NMDARs) on neuronal membranes. Our previous studies have found that icaritin (ICT) exhibits neuroprotective eff...

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Detalles Bibliográficos
Autores principales: Liu, Song, Liu, Chaoming, Xiong, Lijiao, Xie, Jiali, Huang, Cheng, Pi, Rongbiao, Huang, Zhihua, Li, Liangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937872/
https://www.ncbi.nlm.nih.gov/pubmed/33692666
http://dx.doi.org/10.3389/fnins.2021.525615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937872/
https://www.ncbi.nlm.nih.gov/pubmed/33692666
http://dx.doi.org/10.3389/fnins.2021.525615

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