Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements

Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, poss...

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Detalles Bibliográficos
Autores principales: Braverman-Gross, Carmel, Benvenisty, Nissim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937923/
https://www.ncbi.nlm.nih.gov/pubmed/33692757
http://dx.doi.org/10.3389/fendo.2021.622940
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author Braverman-Gross, Carmel
Benvenisty, Nissim
author_facet Braverman-Gross, Carmel
Benvenisty, Nissim
author_sort Braverman-Gross, Carmel
collection PubMed
description Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, possess a great opportunity to model MODY disorders in vitro. Here, we review the models for MODY diseases in hPSCs to date and the molecular lessons learnt from them. We also discuss the limitations and challenges that these types of models are still facing.
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spelling pubmed-79379232021-03-09 Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements Braverman-Gross, Carmel Benvenisty, Nissim Front Endocrinol (Lausanne) Endocrinology Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, possess a great opportunity to model MODY disorders in vitro. Here, we review the models for MODY diseases in hPSCs to date and the molecular lessons learnt from them. We also discuss the limitations and challenges that these types of models are still facing. Frontiers Media S.A. 2021-02-22 /pmc/articles/PMC7937923/ /pubmed/33692757 http://dx.doi.org/10.3389/fendo.2021.622940 Text en Copyright © 2021 Braverman-Gross and Benvenisty http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Braverman-Gross, Carmel
Benvenisty, Nissim
Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements
title Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements
title_full Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements
title_fullStr Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements
title_full_unstemmed Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements
title_short Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements
title_sort modeling maturity onset diabetes of the young in pluripotent stem cells: challenges and achievements
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7937923/
https://www.ncbi.nlm.nih.gov/pubmed/33692757
http://dx.doi.org/10.3389/fendo.2021.622940
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