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Knockdown of hspg2 is associated with abnormal mandibular joint formation and neural crest cell dysfunction in zebrafish

BACKGROUND: Heparan sulfate proteoglycan 2 (HSPG2) encodes for perlecan, a large proteoglycan that plays an important role in cartilage formation, cell adhesion, and basement membrane stability. Mutations in HSPG2 have been associated with Schwartz-Jampel Syndrome (SJS) and Dyssegmental Dysplasia Si...

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Detalles Bibliográficos
Autores principales: Castellanos, Barbara S., Reyes-Nava, Nayeli G., Quintana, Anita M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938484/
https://www.ncbi.nlm.nih.gov/pubmed/33678174
http://dx.doi.org/10.1186/s12861-021-00238-4