Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small‐molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids

BACKGROUND: siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, and effective carriers are needed. RESULTS: Here, we developed cationic solid l...

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Detalles Bibliográficos
Autores principales: Oner, Ezgi, Kotmakci, Mustafa, Baird, Anne-Marie, Gray, Steven G., Debelec Butuner, Bilge, Bozkurt, Emir, Kantarci, Ayse Gulten, Finn, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938557/
https://www.ncbi.nlm.nih.gov/pubmed/33685469
http://dx.doi.org/10.1186/s12951-021-00781-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938557/
https://www.ncbi.nlm.nih.gov/pubmed/33685469
http://dx.doi.org/10.1186/s12951-021-00781-z

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