Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice

INTRODUCTION: Microglial TYROBP (DAP12) is a network hub and driver in sporadic late‐onset Alzheimer's disease (AD). TYROBP is a cytoplasmic adaptor for TREM2 and other receptors, but little is known about its roles and actions in AD. Herein, we demonstrate that endogenous Tyrobp transcription...

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Detalles Bibliográficos
Autores principales: Audrain, Mickael, Haure‐Mirande, Jean‐Vianney, Mleczko, Justyna, Wang, Minghui, Griffin, Jennifer K., St George‐Hyslop, Peter H., Fraser, Paul, Zhang, Bin, Gandy, Sam, Ehrlich, Michelle E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938663/
https://www.ncbi.nlm.nih.gov/pubmed/33314529
http://dx.doi.org/10.1002/alz.12256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938663/
https://www.ncbi.nlm.nih.gov/pubmed/33314529
http://dx.doi.org/10.1002/alz.12256

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