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Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice
INTRODUCTION: Microglial TYROBP (DAP12) is a network hub and driver in sporadic late‐onset Alzheimer's disease (AD). TYROBP is a cytoplasmic adaptor for TREM2 and other receptors, but little is known about its roles and actions in AD. Herein, we demonstrate that endogenous Tyrobp transcription...
Autores principales: | Audrain, Mickael, Haure‐Mirande, Jean‐Vianney, Mleczko, Justyna, Wang, Minghui, Griffin, Jennifer K., St George‐Hyslop, Peter H., Fraser, Paul, Zhang, Bin, Gandy, Sam, Ehrlich, Michelle E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938663/ https://www.ncbi.nlm.nih.gov/pubmed/33314529 http://dx.doi.org/10.1002/alz.12256 |
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