Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function

The inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs), which form tetrameric channels, play pivotal roles in regulating the spatiotemporal patterns of intracellular calcium signals. Mutations in IP(3)Rs have been increasingly associated with many debilitating human diseases such as ataxia, Gi...

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Detalles Bibliográficos
Autores principales: Terry, Lara E., Alzayady, Kamil J., Wahl, Amanda M., Malik, Sundeep, Yule, David I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939385/
https://www.ncbi.nlm.nih.gov/pubmed/33093175
http://dx.doi.org/10.1074/jbc.RA120.015683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939385/
https://www.ncbi.nlm.nih.gov/pubmed/33093175
http://dx.doi.org/10.1074/jbc.RA120.015683

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