Cargando…

Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function

The inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs), which form tetrameric channels, play pivotal roles in regulating the spatiotemporal patterns of intracellular calcium signals. Mutations in IP(3)Rs have been increasingly associated with many debilitating human diseases such as ataxia, Gi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Terry, Lara E., Alzayady, Kamil J., Wahl, Amanda M., Malik, Sundeep, Yule, David I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939385/ https://www.ncbi.nlm.nih.gov/pubmed/33093175 http://dx.doi.org/10.1074/jbc.RA120.015683

Ejemplares similares

Differential Distribution, Clustering, and Lateral Diffusion of Subtypes of the Inositol 1,4,5-Trisphosphate Receptor
por: Pantazaka, Evangelia, et al.
Publicado: (2011)

Regulation of Inositol 1,4,5-Trisphosphate Receptors by cAMP Independent of cAMP-dependent Protein Kinase
por: Tovey, Stephen C., et al.
Publicado: (2010)

Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate–evoked calcium signaling
por: Wilson, Calum, et al.
Publicado: (2019)

Elevated Carbon Dioxide Blunts Mammalian cAMP Signaling Dependent on Inositol 1,4,5-Triphosphate Receptor-mediated Ca(2+) Release
por: Cook, Zara C., et al.
Publicado: (2012)

Missense mutations in inositol 1,4,5-trisphosphate receptor type 3 result in leaky Ca(2+) channels and activation of store-operated Ca(2+) entry
por: Terry, Lara E., et al.
Publicado: (2022)

The Acetyltransferase Activity of the Bacterial Toxin YopJ of Yersinia Is Activated by Eukaryotic Host Cell Inositol Hexakisphosphate
por: Mittal, Rohit, et al.
Publicado: (2010)

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin α(IIb)β(3) Outside-in Signaling
por: Battram, Anthony M., et al.
Publicado: (2017)

Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors
por: Arige, Vikas, et al.
Publicado: (2022)

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12
por: Riedinger, Christiane, et al.
Publicado: (2010)

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity
por: Malfacini, Davide, et al.
Publicado: (2019)

Protein Kinase A Regulatory Subunits in Human Adipose Tissue: Decreased R2B Expression and Activity in Adipocytes From Obese Subjects
por: Mantovani, Giovanna, et al.
Publicado: (2009)

Engineering A-kinase Anchoring Protein (AKAP)-selective Regulatory Subunits of Protein Kinase A (PKA) through Structure-based Phage Selection
por: Gold, Matthew G., et al.
Publicado: (2013)

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells
por: Haushalter, Kristofer J., et al.
Publicado: (2018)

Inhibition of the Cardiac Na(+) Channel Nav1.5 by Carbon Monoxide
por: Elies, Jacobo, et al.
Publicado: (2014)

Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding
por: Telezhkin, Vsevolod, et al.
Publicado: (2012)

α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) and N-Methyl-d-aspartate (NMDA) Receptors Adopt Different Subunit Arrangements
por: Balasuriya, Dilshan, et al.
Publicado: (2013)

Membrane Topology of NAADP-sensitive Two-pore Channels and Their Regulation by N-linked Glycosylation
por: Hooper, Robert, et al.
Publicado: (2011)

Insulin receptor cleavage induced by estrogen impairs insulin signaling
por: Yuasa, Tomoyuki, et al.
Publicado: (2021)

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating
por: Bergsmann, Judith, et al.
Publicado: (2011)

Canonical Transient Receptor Potential 6 (TRPC6), a Redox-regulated Cation Channel
por: Graham, Sarabeth, et al.
Publicado: (2010)

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus
por: Derler, Isabella, et al.
Publicado: (2018)

Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice
por: Uchida, Kunitoshi, et al.
Publicado: (2011)

Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH
por: Lu, Yingying, et al.
Publicado: (2013)

The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na(+) Channel with 4-Fold Symmetry
por: Balasuriya, Dilshan, et al.
Publicado: (2012)

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca(2+) Signals
por: Brailoiu, Eugen, et al.
Publicado: (2010)

Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels?
por: Schwarzer, Sarah, et al.
Publicado: (2010)

Increase in Serum Ca(2+/)Mg(2+) Ratio Promotes Proliferation of Prostate Cancer Cells by Activating TRPM7 Channels
por: Sun, Yuyang, et al.
Publicado: (2013)

Depletion of plasma membrane–associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg(2+), spermine, and pH
por: Zhelay, Tetyana, et al.
Publicado: (2018)

Arresting a Transient Receptor Potential (TRP) Channel: β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4
por: Shukla, Arun K., et al.
Publicado: (2010)

Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA–mDia2 signaling and filopodium formation
por: Argenzio, Elisabetta, et al.
Publicado: (2018)

Resistin Knockout Mice Exhibit Impaired Adipocyte Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Expression
por: Kim, Su-Jin, et al.
Publicado: (2013)

Cysteine Scanning Mutagenesis (Residues Glu(52)–Gly(96)) of the Human P2X1 Receptor for ATP: MAPPING AGONIST BINDING AND CHANNEL GATING
por: Allsopp, Rebecca C., et al.
Publicado: (2011)

P2X Receptor Chimeras Highlight Roles of the Amino Terminus to Partial Agonist Efficacy, the Carboxyl Terminus to Recovery from Desensitization, and Independent Regulation of Channel Transitions
por: Allsopp, Rebecca C., et al.
Publicado: (2013)

Ca(2+) Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors
por: Alswied, Abdullah, et al.
Publicado: (2015)

Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-1 (NEDD4-1) Controls the Sorting of Newly Synthesized Ca(V)1.2 Calcium Channels
por: Rougier, Jean-Sebastien, et al.
Publicado: (2011)

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart
por: Capel, Rebecca A., et al.
Publicado: (2015)

Selective Expression in Carotid Body Type I Cells of a Single Splice Variant of the Large Conductance Calcium- and Voltage-activated Potassium Channel Confers Regulation by AMP-activated Protein Kinase
por: Ross, Fiona A., et al.
Publicado: (2011)

G Protein–Coupled Receptor Kinase 2, With β-Arrestin 2, Impairs Insulin-Induced Akt/Endothelial Nitric Oxide Synthase Signaling in ob/ob Mouse Aorta
por: Taguchi, Kumiko, et al.
Publicado: (2012)

Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders
por: Babinsky, Valerie N., et al.
Publicado: (2016)

Understanding How Components of a Ca(2+) Release-activated Ca(2+) Channel Function♦: The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5gfq3brdof94cl71ebqf90c2pi