PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells

RAS genes are the most commonly mutated in human cancers and play critical roles in tumor initiation, progression, and drug resistance. Identification of targets that block RAS signaling is pivotal to develop therapies for RAS-related cancer. As RAS translocation to the plasma membrane (PM) is essen...

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Detalles Bibliográficos
Autores principales: Huang, Zhangsen, Liu, Mingzhu, Li, Donghe, Tan, Yun, Zhang, Ruihong, Xia, Zhizhou, Wang, Peihong, Jiao, Bo, Liu, Ping, Ren, Ruibao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939389/
https://www.ncbi.nlm.nih.gov/pubmed/33122197
http://dx.doi.org/10.1074/jbc.RA119.011060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939389/
https://www.ncbi.nlm.nih.gov/pubmed/33122197
http://dx.doi.org/10.1074/jbc.RA119.011060

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