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PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells
RAS genes are the most commonly mutated in human cancers and play critical roles in tumor initiation, progression, and drug resistance. Identification of targets that block RAS signaling is pivotal to develop therapies for RAS-related cancer. As RAS translocation to the plasma membrane (PM) is essen...
Autores principales: | Huang, Zhangsen, Liu, Mingzhu, Li, Donghe, Tan, Yun, Zhang, Ruihong, Xia, Zhizhou, Wang, Peihong, Jiao, Bo, Liu, Ping, Ren, Ruibao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939389/ https://www.ncbi.nlm.nih.gov/pubmed/33122197 http://dx.doi.org/10.1074/jbc.RA119.011060 |
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