Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program

Methionine, through S-adenosylmethionine, activates a multifaceted growth program in which ribosome biogenesis, carbon metabolism, and amino acid and nucleotide biosynthesis are induced. This growth program requires the activity of the Gcn4 transcription factor (called ATF4 in mammals), which facili...

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Detalles Bibliográficos
Autores principales: Walvekar, Adhish S., Kadamur, Ganesh, Sreedharan, Sreesa, Gupta, Ritu, Srinivasan, Rajalakshmi, Laxman, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939465/
https://www.ncbi.nlm.nih.gov/pubmed/33122193
http://dx.doi.org/10.1074/jbc.RA120.014248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939465/
https://www.ncbi.nlm.nih.gov/pubmed/33122193
http://dx.doi.org/10.1074/jbc.RA120.014248

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