Seeded fibrils of the germline variant of human λ-III immunoglobulin light chain FOR005 have a similar core as patient fibrils with reduced stability

Systemic antibody light chains (AL) amyloidosis is characterized by deposition of amyloid fibrils derived from a particular antibody light chain. Cardiac involvement is a major risk factor for mortality. Using MAS solid-state NMR, we studied the fibril structure of a recombinant light chain fragment...

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Detalles Bibliográficos
Autores principales: Pradhan, Tejaswini, Annamalai, Karthikeyan, Sarkar, Riddhiman, Huhn, Stefanie, Hegenbart, Ute, Schönland, Stefan, Fändrich, Marcus, Reif, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939468/
https://www.ncbi.nlm.nih.gov/pubmed/33093170
http://dx.doi.org/10.1074/jbc.RA120.016006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939468/
https://www.ncbi.nlm.nih.gov/pubmed/33093170
http://dx.doi.org/10.1074/jbc.RA120.016006

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