N-myristoyltransferase proteins in breast cancer: prognostic relevance and validation as a new drug target

PURPOSE: N-myristoyltransferases 1 and 2 (NMT1 and NMT2) catalyze the addition of 14-carbon fatty acids to the N-terminus of proteins. Myristoylation regulates numerous membrane-bound signal transduction pathways important in cancer biology and the pan-NMT inhibitor PCLX-001 is approaching clinical...

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Detalles Bibliográficos
Autores principales: Mackey, John R., Lai, Justine, Chauhan, Utkarsh, Beauchamp, Erwan, Dong, Wei-Feng, Glubrecht, Darryl, Sim, Yie-Wei, Ghosh, Sunita, Bigras, Gilbert, Lai, Raymond, Berthiaume, Luc G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Preclinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940342/
https://www.ncbi.nlm.nih.gov/pubmed/33398478
http://dx.doi.org/10.1007/s10549-020-06037-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940342/
https://www.ncbi.nlm.nih.gov/pubmed/33398478
http://dx.doi.org/10.1007/s10549-020-06037-y

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