Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish

The molecular pathogenesis of glioblastoma indicates that RTK/Ras/PI3K, RB and TP53 pathways are critical for human gliomagenesis. Here, several transgenic zebrafish lines with single or multiple deletions of nf1, tp53 and rb1 in astrocytes, were established to genetically induce gliomagenesis in ze...

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Detalles Bibliográficos
Autores principales: Luo, Juanjuan, Liu, Pei, Lu, Chunjiao, Bian, Wanping, Su, Dongsheng, Zhu, Chenchen, Xie, Shaolin, Pan, Yihang, Li, Ningning, Cui, Wei, Pei, De-Sheng, Yang, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940501/
https://www.ncbi.nlm.nih.gov/pubmed/33279959
http://dx.doi.org/10.1093/brain/awaa404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940501/
https://www.ncbi.nlm.nih.gov/pubmed/33279959
http://dx.doi.org/10.1093/brain/awaa404

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