Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes

Immunostimulatory gene therapy utilizing oncolytic viruses (OVs) as gene vehicles is a promising immunotherapy for cancer. Since viruses are immunogenic, systemic delivery can be troublesome due to neutralizing antibodies. Nevertheless, local delivery by intratumoral injection seems to induce system...

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Detalles Bibliográficos
Autores principales: Labani-Motlagh, Alireza, Naseri, Sedigheh, Wenthe, Jessica, Eriksson, Emma, Loskog, Angelica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940707/
https://www.ncbi.nlm.nih.gov/pubmed/33738337
http://dx.doi.org/10.1016/j.omto.2021.02.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940707/
https://www.ncbi.nlm.nih.gov/pubmed/33738337
http://dx.doi.org/10.1016/j.omto.2021.02.007

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