Replacing thymine with a strongly pairing fifth Base: A combined quantum mechanics and molecular dynamics study

The non-natural ethynylmethylpyridone C-nucleoside (W), a thymidine (T) analogue that can be incorporated in oligonucleotides by automated synthesis, has recently been reported to form a high fidelity base pair with adenosine (A) and to be well accommodated in B-DNA duplexes. The enhanced binding af...

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Detalles Bibliográficos
Autores principales: Chawla, Mohit, Gorle, Suresh, Shaikh, Abdul Rajjak, Oliva, Romina, Cavallo, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940798/
https://www.ncbi.nlm.nih.gov/pubmed/33738080
http://dx.doi.org/10.1016/j.csbj.2021.02.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940798/
https://www.ncbi.nlm.nih.gov/pubmed/33738080
http://dx.doi.org/10.1016/j.csbj.2021.02.006

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