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Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue
The accumulation of proteins into insoluble aggregates is a common feature of several neurodegenerative diseases. Aggregated α-synuclein is a major component of Lewy bodies that pathologically define Parkinson's disease (PD). Here, we present methods for the detection of pathogenic conformation...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941090/ https://www.ncbi.nlm.nih.gov/pubmed/33733241 http://dx.doi.org/10.1016/j.xpro.2021.100372 |