Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature

BACKGROUND: Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards hypermethylation in most tissues, including brain, and includes pan-tissue differential methylation. The molecular mechanisms involve the overexpression of genes related to...

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Detalles Bibliográficos
Autores principales: Laufer, Benjamin I., Gomez, J. Antonio, Jianu, Julia M., LaSalle, Janine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942011/
https://www.ncbi.nlm.nih.gov/pubmed/33750431
http://dx.doi.org/10.1186/s13072-021-00387-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942011/
https://www.ncbi.nlm.nih.gov/pubmed/33750431
http://dx.doi.org/10.1186/s13072-021-00387-7

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