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Molecular basis for functional connectivity between the voltage sensor and the selectivity filter gate in Shaker K(+) channels
In Shaker K(+) channels, the S4-S5 linker couples the voltage sensor (VSD) and pore domain (PD). Another coupling mechanism is revealed using two W434F-containing channels: L361R:W434F and L366H:W434F. In L361R:W434F, W434F affects the L361R VSD seen as a shallower charge-voltage (Q-V) curve that cr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943188/ https://www.ncbi.nlm.nih.gov/pubmed/33620313 http://dx.doi.org/10.7554/eLife.63077 |