Redox controls RecA protein activity via reversible oxidation of its methionine residues

Reactive oxygen species (ROS) cause damage to DNA and proteins. Here, we report that the RecA recombinase is itself oxidized by ROS. Genetic and biochemical analyses revealed that oxidation of RecA altered its DNA repair and DNA recombination activities. Mass spectrometry analysis showed that exposu...

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Detalles Bibliográficos
Autores principales: Henry, Camille, Loiseau, Laurent, Vergnes, Alexandra, Vertommen, Didier, Mérida-Floriano, Angela, Chitteni-Pattu, Sindhu, Wood, Elizabeth A, Casadesús, Josep, Cox, Michael M, Barras, Frédéric, Ezraty, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943192/
https://www.ncbi.nlm.nih.gov/pubmed/33605213
http://dx.doi.org/10.7554/eLife.63747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943192/
https://www.ncbi.nlm.nih.gov/pubmed/33605213
http://dx.doi.org/10.7554/eLife.63747

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