The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer’s disease mutations

Plaques of the amyloid beta (Aß) peptide are a pathological hallmark of Alzheimer’s disease (AD), the most common form of dementia. Mutations in Aß also cause familial forms of AD (fAD). Here, we use deep mutational scanning to quantify the effects of >14,000 mutations on the aggregation of Aß. T...

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Detalles Bibliográficos
Autores principales: Seuma, Mireia, Faure, Andre J, Badia, Marta, Lehner, Ben, Bolognesi, Benedetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943193/
https://www.ncbi.nlm.nih.gov/pubmed/33522485
http://dx.doi.org/10.7554/eLife.63364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943193/
https://www.ncbi.nlm.nih.gov/pubmed/33522485
http://dx.doi.org/10.7554/eLife.63364

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