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Role of Alpelisib in the Treatment of PIK3CA-Mutated Breast Cancer: Patient Selection and Clinical Perspectives

The PI3K/AKT/mTOR pathway has long been known to play a major role in the growth and survival of cancer cells. Breast tumors often harbor PIK3CA gene alterations, which therefore constitute a rational drug target. However, it has taken many years to demonstrate clinically-relevant efficacy of PI3K i...

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Detalles Bibliográficos
Autores principales: Chang, Dwan-Ying, Ma, Wei-Li, Lu, Yen-Shen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943556/
https://www.ncbi.nlm.nih.gov/pubmed/33707948
http://dx.doi.org/10.2147/TCRM.S251668