A selective small-molecule inhibitor of c-Met suppresses keloid fibroblast growth in vitro and in a mouse model

Keloids, tumor-like lesions that result from excessive scar formation, have no definitive treatment modality. Activation of c-mesenchymal-epithelial transition factor (c-Met) promotes cell proliferation and survival. Selective c-Met inhibitors, such as PHA-665752, may attenuate the activity of keloi...

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Detalles Bibliográficos
Autores principales: Choi, Min-Ha, Kim, Jinhyun, Ha, Jeong Hyun, Park, Ji-Ung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943593/
https://www.ncbi.nlm.nih.gov/pubmed/33750878
http://dx.doi.org/10.1038/s41598-021-84982-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943593/
https://www.ncbi.nlm.nih.gov/pubmed/33750878
http://dx.doi.org/10.1038/s41598-021-84982-4

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