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A selective small-molecule inhibitor of c-Met suppresses keloid fibroblast growth in vitro and in a mouse model
Keloids, tumor-like lesions that result from excessive scar formation, have no definitive treatment modality. Activation of c-mesenchymal-epithelial transition factor (c-Met) promotes cell proliferation and survival. Selective c-Met inhibitors, such as PHA-665752, may attenuate the activity of keloi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943593/ https://www.ncbi.nlm.nih.gov/pubmed/33750878 http://dx.doi.org/10.1038/s41598-021-84982-4 |