Disrupting upstream translation in mRNAs is associated with human disease

Ribosome-profiling has uncovered pervasive translation in non-canonical open reading frames, however the biological significance of this phenomenon remains unclear. Using genetic variation from 71,702 human genomes, we assess patterns of selection in translated upstream open reading frames (uORFs) i...

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Detalles Bibliográficos
Autores principales: Lee, David S. M., Park, Joseph, Kromer, Andrew, Baras, Aris, Rader, Daniel J., Ritchie, Marylyn D., Ghanem, Louis R., Barash, Yoseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943595/
https://www.ncbi.nlm.nih.gov/pubmed/33750777
http://dx.doi.org/10.1038/s41467-021-21812-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943595/
https://www.ncbi.nlm.nih.gov/pubmed/33750777
http://dx.doi.org/10.1038/s41467-021-21812-1

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