NLRP3 Deficiency Protects Against Intermittent Hypoxia-Induced Neuroinflammation and Mitochondrial ROS by Promoting the PINK1-Parkin Pathway of Mitophagy in a Murine Model of Sleep Apnea

Obstructive sleep apnea (OSA) associated neurocognitive impairment is mainly caused by chronic intermittent hypoxia (CIH)-triggered neuroinflammation and oxidative stress. Previous study has demonstrated that mitochondrial reactive oxygen species (mtROS) was pivotal for hypoxia-related tissue injury...

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Detalles Bibliográficos
Autores principales: Wu, Xu, Gong, Linjing, Xie, Liang, Gu, Wenyu, Wang, Xinyuan, Liu, Zilong, Li, Shanqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943742/
https://www.ncbi.nlm.nih.gov/pubmed/33717152
http://dx.doi.org/10.3389/fimmu.2021.628168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943742/
https://www.ncbi.nlm.nih.gov/pubmed/33717152
http://dx.doi.org/10.3389/fimmu.2021.628168

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