Epigenetic modulation reveals differentiation state specificity of oncogene addiction

Hyperactivation of the MAPK signaling pathway motivates the clinical use of MAPK inhibitors for BRAF-mutant melanomas. Heterogeneity in differentiation state due to epigenetic plasticity, however, results in cell-to-cell variability in the state of MAPK dependency, diminishing the efficacy of MAPK i...

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Detalles Bibliográficos
Autores principales: Khaliq, Mehwish, Manikkam, Mohan, Martinez, Elisabeth D., Fallahi-Sichani, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943789/
https://www.ncbi.nlm.nih.gov/pubmed/33750776
http://dx.doi.org/10.1038/s41467-021-21784-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943789/
https://www.ncbi.nlm.nih.gov/pubmed/33750776
http://dx.doi.org/10.1038/s41467-021-21784-2

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