Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington’s disease

Kynurenine 3-monooxygenase (KMO) regulates the levels of neuroactive metabolites in the kynurenine pathway (KP), dysregulation of which is associated with Huntington’s disease (HD) pathogenesis. KMO inhibition leads to increased levels of neuroprotective relative to neurotoxic metabolites, and has b...

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Detalles Bibliográficos
Autores principales: Bondulich, Marie Katrin, Fan, Yilan, Song, Yeojin, Giorgini, Flaviano, Bates, Gillian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943810/
https://www.ncbi.nlm.nih.gov/pubmed/33750843
http://dx.doi.org/10.1038/s41598-021-84858-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943810/
https://www.ncbi.nlm.nih.gov/pubmed/33750843
http://dx.doi.org/10.1038/s41598-021-84858-7

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