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The less conserved metal-binding site in human CRISP1 remains sensitive to zinc ions to permit protein oligomerization

Cysteine-rich secretory proteins (CRISPs) are a subgroup of the CRISP, antigen 5 and PR-1 (CAP) superfamily that is characterized by the presence of a conserved CAP domain. Two conserved histidines in the CAP domain are proposed to function as a Zn(2+)-binding site with unknown function. Human CRISP...

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Detalles Bibliográficos
Autores principales: Sheng, Jie, Gadella, Bart M., Olrichs, Nick K., Kaloyanova, Dora V., Helms, J. Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943821/
https://www.ncbi.nlm.nih.gov/pubmed/33750840
http://dx.doi.org/10.1038/s41598-021-84926-y