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Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Shaker potassium channel
Voltage-gated potassium (K(V)) channels can be opened by negatively charged resin acids and their derivatives. These resin acids have been proposed to attract the positively charged voltage-sensor helix (S4) toward the extracellular side of the membrane by binding to a pocket located between the lip...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944402/ https://www.ncbi.nlm.nih.gov/pubmed/33683319 http://dx.doi.org/10.1085/jgp.202012676 |