Identification of pathogenic variants in cancer genes using base editing screens with editing efficiency correction

BACKGROUND: Millions of nucleotide variants are identified through cancer genome sequencing and it is clinically important to identify the pathogenic variants among them. By introducing base substitutions at guide RNA target regions in the genome, CRISPR-Cas9-based base editors provide the possibili...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Changcai, Li, Guangyu, Wu, Jiayu, Liang, Junbo, Wang, Xiaoyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945310/
https://www.ncbi.nlm.nih.gov/pubmed/33691754
http://dx.doi.org/10.1186/s13059-021-02305-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945310/
https://www.ncbi.nlm.nih.gov/pubmed/33691754
http://dx.doi.org/10.1186/s13059-021-02305-2

Ejemplares similares