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Comparative metabolomics analysis of amphotericin B high-yield mechanism for metabolic engineering

BACKGROUND: The polyene macrocyclic compound amphotericin B (AmB) is an important antifungal antibiotic for the clinical treatment of invasive fungal infections. To rationally guide the improvement of AmB production in the main producing strain Streptomyces nodosus, comparative metabolomics analysis...

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Detalles Bibliográficos
Autores principales:	Zhang, Bo, Chen, Yu, Jiang, Sheng-Xian, Cai, Xue, Huang, Kai, Liu, Zhi-Qiang, Zheng, Yu-Guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945361/ https://www.ncbi.nlm.nih.gov/pubmed/33750383 http://dx.doi.org/10.1186/s12934-021-01552-z

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