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Virus vaccines: proteins prefer prolines

Most viral vaccines are based on inducing neutralizing antibodies (NAbs) against the virus envelope or spike glycoproteins. Many viral surface proteins exist as trimers that transition from a pre-fusion state when key NAb epitopes are exposed to a post-fusion form in which the potential for virus-ce...

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Detalles Bibliográficos
Autores principales: Sanders, Rogier W., Moore, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945883/
https://www.ncbi.nlm.nih.gov/pubmed/33705704
http://dx.doi.org/10.1016/j.chom.2021.02.002