Cargando…

Epigenome wide association study of response to methotrexate in early rheumatoid arthritis patients

AIM: To identify differentially methylated positions (DMPs) and regions (DMRs) that predict response to Methotrexate (MTX) in early rheumatoid arthritis (RA) patients. MATERIALS AND METHODS: DNA from baseline peripheral blood mononuclear cells was extracted from 72 RA patients. DNA methylation, quan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gosselt, Helen R., Vallerga, Costanza L., Mandaviya, Pooja R., Lubberts, Erik, Hazes, Johanna M. W., de Jonge, Robert, Heil, Sandra G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946177/ https://www.ncbi.nlm.nih.gov/pubmed/33690661 http://dx.doi.org/10.1371/journal.pone.0247709

Ejemplares similares

Identification of Metabolic Biomarkers in Relation to Methotrexate Response in Early Rheumatoid Arthritis
por: Gosselt, Helen R., et al.
Publicado: (2020)

Validation of a Prognostic Multivariable Prediction Model for Insufficient Clinical Response to Methotrexate in Early Rheumatoid Arthritis and Its Clinical Application in Evidencio
por: Gosselt, Helen R., et al.
Publicado: (2020)

Complex Machine-Learning Algorithms and Multivariable Logistic Regression on Par in the Prediction of Insufficient Clinical Response to Methotrexate in Rheumatoid Arthritis
por: Gosselt, Helen R., et al.
Publicado: (2021)

Higher baseline global leukocyte DNA methylation is associated with MTX non-response in early RA patients
por: Gosselt, Helen R., et al.
Publicado: (2019)

Altered DNA methylation in children born to mothers with rheumatoid arthritis during pregnancy
por: Ince-Askan, Hilal, et al.
Publicado: (2019)

Achieving sustained minimal disease activity with methotrexate in early interleukin 23-driven early psoriatic arthritis
por: den Braanker, Hannah, et al.
Publicado: (2020)

CCR6(+) Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis
por: Paulissen, Sandra M. J., et al.
Publicado: (2015)

Nano Methotrexate versus Methotrexate in Targeting Rheumatoid Arthritis
por: Salem, Heba F., et al.
Publicado: (2022)

Methotrexate Hepatotoxicity in Patients with Rheumatoid Arthritis
por: Sotoudehmanesh, R, et al.
Publicado: (2010)

Development and validation of a prognostic multivariable model to predict insufficient clinical response to methotrexate in rheumatoid arthritis
por: de Rotte, Maurits C. F. J., et al.
Publicado: (2018)

Methotrexate alone and methotrexate combined with etanercept in treatment of rheumatoid arthritis
por: Rexhepi, Sylejman, et al.
Publicado: (2012)

Adherence to Methotrexate therapy in Rheumatoid Arthritis
por: Arshad, Nasim, et al.
Publicado: (2016)

Prevalence of methotrexate intolerance in rheumatoid arthritis and psoriatic arthritis
por: Bulatović Ćalasan, Maja, et al.
Publicado: (2013)

From patients with arthralgia, pre-RA and recently diagnosed RA: what is the current status of understanding RA pathogenesis?
por: Molendijk, Marlieke, et al.
Publicado: (2018)

Treatment efficacy and methotrexate-related toxicity in patients with rheumatoid arthritis receiving methotrexate in combination with adalimumab
por: Burmester, Gerd R, et al.
Publicado: (2017)

Reply to P-A Dugué et al.
por: Mandaviya, Pooja R, et al.
Publicado: (2020)

Global DNA (hydroxy)methylation is stable over time under several storage conditions and temperatures
por: Gosselt, Helen R., et al.
Publicado: (2020)

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in Rheumatoid Arthritis
por: Liu, Yun, et al.
Publicado: (2013)

Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate
por: Altawil, Reem, et al.
Publicado: (2016)

Plasma Metabolome Normalization in Rheumatoid Arthritis Following Initiation of Methotrexate and the Identification of Metabolic Biomarkers of Efficacy
por: Medcalf, Matthew R., et al.
Publicado: (2021)

Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis
por: Muller, Ittai B, et al.
Publicado: (2020)

Genetic Variants Associated with Methotrexate Efficacy and Toxicity in Early Rheumatoid Arthritis: Results from the Treatment of Early Aggressive Rheumatoid Arthritis Trial
por: Aslibekyan, Stella, et al.
Publicado: (2013)

Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study
por: Svendsen, Anders J., et al.
Publicado: (2016)

Identification of novel meQTLs strongly associated with rheumatoid arthritis by large‐scale epigenome‐wide analysis
por: Tang, Guoping, et al.
Publicado: (2022)

Role of ultrasonography in diagnosing early rheumatoid arthritis and remission of rheumatoid arthritis - a systematic review of the literature
por: Ten Cate, David F, et al.
Publicado: (2013)

Achieving pain control in early rheumatoid arthritis with baricitinib monotherapy or in combination with methotrexate versus methotrexate monotherapy
por: Taylor, Peter C., et al.
Publicado: (2022)

Methotrexate treatment in early psoriatic arthritis in comparison to rheumatoid arthritis: an observational nationwide study
por: Lindström, Ulf, et al.
Publicado: (2023)

Exhaled nitric oxide in early rheumatoid arthritis and effects of methotrexate treatment
por: Weitoft, Tomas, et al.
Publicado: (2022)

Etanercept or Methotrexate Withdrawal in Rheumatoid Arthritis Patients in Sustained Remission
por: Curtis, Jeffrey R., et al.
Publicado: (2021)

Patient’s experience with subcutaneous and oral methotrexate for the treatment of rheumatoid arthritis
por: Curtis, J. R., et al.
Publicado: (2016)

Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies
por: van Rooij, Jeroen, et al.
Publicado: (2019)

Recommendations for optimizing methotrexate treatment for patients with rheumatoid arthritis
por: Bello, Alfonso E, et al.
Publicado: (2017)

Safety Profile of Methotrexate Therapy in Patients With Rheumatoid Arthritis
por: Mustafa, Syed Hassan, et al.
Publicado: (2022)

Rheumatoid arthritis and Hailey‐Hailey disease treated with methotrexate
por: Mestre, Beatriz, et al.
Publicado: (2022)

Efficacy of etanercept in combination with methotrexate in moderate-to-severe rheumatoid arthritis is not dependent on methotrexate dosage
por: Gallo, G, et al.
Publicado: (2016)

The epigenome of synovial fibroblasts: an underestimated therapeutic target in rheumatoid arthritis
por: Frank-Bertoncelj, Mojca, et al.
Publicado: (2014)

Subfertility in Women With Rheumatoid Arthritis and the Outcome of Fertility Assessments
por: Brouwer, Jenny, et al.
Publicado: (2017)

Pharmacogenomics of Methotrexate Membrane Transport Pathway: Can Clinical Response to Methotrexate in Rheumatoid Arthritis Be Predicted?
por: Lima, Aurea, et al.
Publicado: (2015)

Effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis
por: Isozaki, Takeo, et al.
Publicado: (2010)

The impact of different (rheumatoid) arthritis phenotypes on patients’ lives
por: Luurssen-Masurel, Nathalie, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r09r6secgr0ehq4fgoaddpc08j