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yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis

Piwi-interacting RNAs (piRNAs) play critical roles in protecting germline genome integrity and promoting normal spermiogenic differentiation. In mammals, there are two populations of piRNAs: pre-pachytene and pachytene. Transposon-rich pre-pachytene piRNAs are expressed in fetal and perinatal germ c...

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Detalles Bibliográficos
Autores principales: Guan, Yongjuan, Keeney, Scott, Jain, Devanshi, Wang, P. Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946307/
https://www.ncbi.nlm.nih.gov/pubmed/33635934
http://dx.doi.org/10.1371/journal.pgen.1009265