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Ancestral haplotype reconstruction in endogamous populations using identity-by-descent
In this work we develop a novel algorithm for reconstructing the genomes of ancestral individuals, given genotype or sequence data from contemporary individuals and an extended pedigree of family relationships. A pedigree with complete genomes for every individual enables the study of allele frequen...
Autores principales: | Finke, Kelly, Kourakos, Michael, Brown, Gabriela, Dang, Huyen Trang, Tan, Shi Jie Samuel, Simons, Yuval B., Ramdas, Shweta, Schäffer, Alejandro A., Kember, Rachel L., Bućan, Maja, Mathieson, Sara |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946327/ https://www.ncbi.nlm.nih.gov/pubmed/33635861 http://dx.doi.org/10.1371/journal.pcbi.1008638 |
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