α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms

No disease-modifying therapy is currently available for Parkinson’s disease (PD), the second most common neurodegenerative disease. The long nonmotor prodromal phase of PD is a window of opportunity for early detection and intervention. However, we lack the pathophysiological understanding to develo...

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Detalles Bibliográficos
Autores principales: Chiu, Wei-Hua, Kovacheva, Lora, Musgrove, Ruth E., Arien-Zakay, Hadar, Koprich, James B., Brotchie, Jonathan M., Yaka, Rami, Ben-Zvi, Danny, Hanani, Menachem, Roeper, Jochen, Goldberg, Joshua A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946367/
https://www.ncbi.nlm.nih.gov/pubmed/33692101
http://dx.doi.org/10.1126/sciadv.abd3994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946367/
https://www.ncbi.nlm.nih.gov/pubmed/33692101
http://dx.doi.org/10.1126/sciadv.abd3994

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